Programme
Mercredi 12 octobre 2016,
17:30 – 19:30 : Enregistrement et cocktail de bienvenue
19:30 : Dîner
Mercredi 12 octobre 2016 / Session 1
Moderateurs : Olivier Hérault, Pierre Lutz
20:30 – 20:45 : Conférence inaugurale :
Olivier Hérault (président du CHO)
20:45 – 21:30 : Emmanuelle Passegué (UCSF, San Francisco, USA)
Conférence plénière: "Hematopoietic Stem Cell Function in Stress, Disease and Aging"
Jeudi 13 octpobre 2016 Session 2
Moderateurs : Michel Aurrand-Lions, Béatrice Romagnolo
8:30 – 9:15 : Triantafyllos Chavakis (Univ Carl Gustav Carus, Dresden, Germany)
Del1 in the hematopoietic stem cell niche
9:15 – 9:30 : Christelle Freitas (INSERM UMR 996, Clamart, France)
Impact of a gain-of-function mutation of Cxcr4 on hematopoiesis in mice
9:30 – 9:45 : Nicola Sunter (CNRS UMR 7292, Tours, France)
Modelling the Leukaemic Niche in 3D: an evaluation of three potential sources of stromal cells
9:45 – 10:00 : Présentations des posters . Session I
10:00 – 10:30 : Pause
10:30 – 10:45 : Mario Flores Violante (INSERM U1052, CNRS UMR5286, Lyon France)
Identification of the role of the BMP pathway in Acute Myeloid Leukemia (AML) through the correlation with DNp73 and NANOG, themselves associated with leukemic stem cells
10:45 – 11:00 : Prashanth Kumar Kandalla (CNRS INSERM CIML, Marseille, France)
M-CSF improves protection against bacterial, fungal and viral infections after hematopoietic stem/progenitor cell transplantation
11:00 – 11:45 : Maria Elena Fernandez-Sanchez (Institut Curie, Paris, France)
Mechanosensitivity of junctional beta-catenin: from mesoderm mechanotransductive evolutionary origins to tumourogenic mechanical induction
12:00 : Déjeuner
Jeudi 13 octobre 2016 Session 3
Moderateurs : Celio Pouponnot, Pierre Lutz
15:00 – 15:45 : Béatrice Romagnolo (Institut Cochin, Paris, France)
Critical roles for autophagy inhibition in colorectal cancer
15:45 – 16:00 : Stéphane Manenti (CRCT, Toulouse, France)
FLT3-ITD receptor induces ATF4-dependent autophagy in acute myeloid leukemia
16:00 – 16:15 : Camille Spinner (UMR 5089, CNRS-UPS, IPBS, Toulouse, France)
Role of the ASB2a E3 ubiquitin ligase in tumor development
16:15 – 16:30 : Présentations de posters. Session II
16:30 – 17:00 : Pause
17:00 – 17:15 : Dominique Bluteau (INSERM U944, CNRS UMR 7212, IUH, Paris, France)
FANCV (REV7/MAD2L2), a new Fanconi anemia gene
17:15 – 17:30 : Daniela Barbieri (INSERM U1170, IGR, Villejuif, France)
Thrombopoietin restrains retrotransposon-mediated DNA damage in hematopoietic stem cells by promoting an anti-viral innate immune response
17:30 – 17:45 : Edwige Voisset (King’s college London, London, UK)
Pml nuclear body disruption cooperates in APL pathogenesis, impacting DNA damage repair pathways
17:45 – 18:30 : Bruno Amati (IIT and IEO, Milan, Italy)
Transcriptional programs, genetic modifiers and therapeutic targets in Myc-driven tumors
18:30 : Présentations de posters - pause
20:30 : Dîner
Vendredi 14 octobre 2016 Session 4
Moderateurs : Evelyne Lauret, Olivier Herault
9:00 – 9:45 : Hana Raslova (Institut Gustave Roussy, Villejuif, France)
Inherited thrombocytopenias predisposing to hematological malignancies
9:45 – 10:00 : Lise Secardin (INSERM UMR 1170, IGR, Villejuif, France)
Modélisation des néoplasmes myéloprolifératifs (NMP) mutés pour la calréticuline par génération de cellules souches induites à la pluripotence (iPSC)
10:00 – 10:15 : Anna Guadall (INSERM U1131, Paris, France)
Endothelial cells harbouring JAK2V617F mutation display pro-thrombotic characteristics
10:15 – 10:45 : Pause
10:45 – 11:00 : Lydie Debaize (CNRS UMR 6290, IGDR, Rennes, France)
Two hematopoietic transcription factors, RUNX1 and FUBP1, control jointly the expression of c-KIT oncogene in pre-B lymphoblasts
11:00 – 11:15 : Amelle Vandevelde (CNRS UMR7258, INSERM U1068, CRCM, Marseille, France)
Role of PLZF in hematopoietic stem cell stress response
11:15 – 12:00 : Philippe Kastner (IGBMC, Strasbourg, France)
Function of Ikaros family transcription factor in hematopoiesis
12:00 : Déjeuner
13:30 – 15:30 : Temps libre
Vendredi 14 octobre 2016 Session 5
Moderateurs : Thomas Mercher, Laurent Delva
15:30 – 16:15 : urg Schwaller (Dept of Biomedicine University Hospital, Basel, Switzerland)
Insights on origin and targets of hematopoietic malignancies by conditional transgenic mouse models
16:15 – 16:30 : Anne Largeot (CRUM MI, Manchester, UK)
Identification of new potential therapeutic targets in MOZ- and MLL- related acute myeloblastic leukaemia
16:30 – 16:45 : Gaëlle Cordonnier (INSERM U 1151, INEM, Paris, France)
CBFb-SMMHC directly regulates ribosomal gene transcription and alters ribosome biogenesis
16:45 – 17:00 : Pause
17:00 – 17:15 : Amélie Guitart (SCRM, Edinburgh, UK)
The role of Cited 2 in haematopoiesis regulation
17:15 – 17:30 : Anne-Sophie Alary (INSERM U1016, Institut Cochin, Paris, France)
Gene expression and alternative splicing datasets analyses of MDS with ring sideroblasts highlight alternative branchpoint usage in genes involved in iron metabolism and erythropoiesis.
17:30 – 18:15 : Jacques Ghysdael (UMR3348 CNRS-Institut Curie, Orsay)
Novel targeted therapies in T cell acute lymphoblastic leukemia
Vendredi 14 octobre 2016, 18:15 – 19:00 : Assemblée Générale
Vendredi 14 octobre 2016, 20:00 : Dîner
Vendredi 14 octobre 2016, 21:00 : Soirée de gala
Samedi 15 octobre 2016, Session 6
Moderateurs : Françoise Pflumio, Isabelle André-Schmutz
8:30 – 9:15 : Marc Piechaczyk (IGMM, UMR5535 CNRS, Montpellier, France)
The ROS/SUMO axis is involved in the response of chemosensitive acute myeloid leukemia (AML) cells to chemotherapeutics and constitutes a potential target to overcome chemoresistance
9:15 – 9:30 : Bochra Zidi (CNRS UMR 7258, INSERM U1068, CRCM, Marseille, France)
Aging-associated defects in hematopoietic differentiation involve redox regulation by the stress protein TP53INP1
9:30 – 9:45 : Mathieu Meunier (TIMC-Therex, CNRS UMR 5525, Grenoble, France)
Mechanisms of improvement of erythropoiesis with low dose deferasirox in low risk myelodysplastic syndromes
9:45 – 10:00 : Pause
10:00 – 10:15 : Coralie Hoarau-Aveila (INSERM U1037, CRCT, Toulouse, France)
Methylated miR-125b gene is a promising biomarker of resistance to chemotherapy in ALK-positive cells with diagnostic potential
10:15 – 11:00 : Michael Rieger (LOEWE Center for Cell and Gene Therapy Frankfurt, Germany)
Hematopoietic stem cell self-renewal and differentiation control at single cell resolution
11:15 – 11:30 : Remise des prix
Fin du congrès