Programme
Mercredi 14 octobre 2015
5:30 -7:30 p.m : Enregistrement et cocktail de bienvenue cocktail
7:30 p.m :Dîner
Mercredi 14 octobre 2015. Session 1
Moderateur : Véronique Maguer-Satta
9:00 - 9:15 p.m : Conférence d'ouverture :
Véronique Maguer–Satta (Président du CHO)
9:15 - 10:00 p.m : Tariq ENVER (UCL, London, UK)
Conférence plénière : Origins and Evolution of Childhood Leukaemia
Jeudi 15 octobre 2015. Session 2
Moderateurs: Thierry Jaffredo – Françoise Pflumio
8:30 - 9:15 : Erika Brunet (Musée Nal D’Histoire, Paris)
Cancer translocations using genome-editing methods (CRISPR/Cas9) to understand oncogenesis
9:15 - 9:30 : Bérengère De Laval (CIML, Inserm U1104, CNRS UMR7280, Marseille)
Differential proliferative response and early myeloid commitment of HSC depending on previous infection history
9:30 - 9:45 : Marie-Laure Arcangeli (CEA-iRCM-INSERM U967, Fontenay-aux- Roses)
Effects of Low doses of ionizing radiations on human Hematopoietic Stem cell functions
9:45 - 10:00 : Présentations de posters, session 1.
10:00 - 10:30 : Pause
10:30 - 10:45 : Alessandro Donada (INSERM U1170, IGR, Villejuif)
Modeling of the pre-leukemic state in ANKRD26-thrombocytopenia by induced pluripotent stem cells
10:45 -11:00 : Romain Aucagne (IRIC, Montréal, QC, Canada)
Centrosomal localization of BMI1 reveals a key role for Polycomb proteins in coordinating centrosome duplication and cell cycle progression
11:00 - 11:45 : Ido Amit (Weizmann Institute of Science, Rehovot, Israel)
Shaping the blood: Lessons from chromatin and single cell RNA-seq dynamics
11:45 a.m : Déjeuner
Jeudi 15 octobre 2015. Session 3
Moderateurs: Michèle Souyri – Pierre Lutz
15:00 - 15:45 :Thierry Jaffredo (UMR7622, UPMC, Paris, France).
Hemogenic endothelium during development and beyond
15:45 - 16:00 : Carine Halfon-Domenech (CNRS UMR 7622, INSERM U1156, UPMC PARIS 6)
Exhaustion in myeloid lineage and very early defect in HSPC pool: an embryonic origin of Fanconi haematological disorders
16:00 - 16:15 :Michèle Crozatier (CBD /UMR 5547 TOULOUSE III)
Vascular control of the Drosophila haematopoietic niche: role of Slit/Robo signalling
16:15 - 16:30 : Présentations de posters. Session II
16:30 - 17:00 : Pause
17:00 - 17:15 : Marielle Balzano-Foucher (CRCM - Inserm U1068 - CNRS UMR 7258 Marseille)
Hematopoietic Stem Cell and early B cell differentiation programs depend on a unique multispecific perivascular niche
17:15 - 17:30 : Grégoire Stik (CNRS UMR 7622, Inserm 1156, IBPS, UPMC Paris 6)
Roles of Exosomes in the Hematopoietic Stem Cell-Supporting Capacity of Stromal Cells
17:30 - 17:45 : Elodie Grockowiak (Inserm U1052-CNRS UMR5286, Lyon)
BMP signalling deregulations persist in CML resistant patients under treatments and contribute to LSC persistence independently of BCR- ABL
17:45 - 18:30 p.m : Daniela Krause (Georg Speyer Haus, Frankfurt, Germany).
A hostel for the hostile : Characterising and therapeutic targeting of the leukaemic stem cell niche
18:30 p.m : Pause - Session posters
8:30 p.m : Dîner
Vendredi 16 octobre 2015. Session 4
Moderateurs : Michael Sieweke – Frédéric Mazurier
9:00 - 9:45 : Eric Solary (U1170 INSERM, IGR, Villejuif, France)
Chronic myelomonocytic leukemia: strategies to improve diagnosis and care
9:45 - 10:00 : Kevin Rouault-Pierre (Haematopoietic Stem Cell Lab, London)
Myelodysplastic Syndrome-Initiating Cells can propagate from Multipotent Progenitor compartment
10:00 - 10:15 : Laetitia Saint Paul (Inserm U866, Dijon)
Localization of the CD45 phosphatase within lipid rafts is crucial for AML maintenance
10:15 - 10:45 : Pause
10:45 - 11:00 : Florence Zylbersztejn (U1163/U1052, Lyon)
Vitamin D receptor controls stemness in acute myeloid leukemia
11:00 - 11:15 : Cathy Ignacimouttou (INSERM U1170, IGR, Villejuif)
Deregulation of both ETO2 and GLIS2 functions in acute megakaryoblastic leukemia
11:15 - 12:00 : Ruud Delwel (Erasmus, Rotterdam, Holland)
Molecular breakdown of acute myeloid leukemia with aberrant expression of EVI1 and GATA2
12:00 : Déjeuner
13:30 - 15:30 p.m : temps libre
Vendredi 16 octobre 2015. Session 5
Moderateurs : Thomas Mercher – Olivier Hérault
15:30 - 16:15 : Carmen Garrido (INSERM UMR866, Université de Bourgogne, Dijon).
HspPathies: role of HSP70 in erythropoietic disorders
16:15 - 16:30 : Guillaume Giraud (Erasmus Medical Center, Rotterdam, Pays-Bas)
Fli-1 and the Ldb1 complex: A group of friends playing together during megakaryopoiesis and leukemia
16:30 - 16:45 : Lucie Laplane (INSERM U1170, IGR, Villejuif)
CSC and Clonal Evolution, an Epistemological Investigation
16:45 - 17:00 : Pause
17:00 - 17:15 : David Garrick (INSERM U1126, Saint Louis)
miR-125b-SUV39H1 pathway regulates heterochromatin and B lymphoid differentiation of human HSC with age
17:15 - 17:30 : Cyril Esnault (IGMM, UMR5535 CNRS, Montpellier)
A chromatin modification cascade set the Ras-dependent immediate transcriptional program
17:30 - 18:15 : Roger Patient (Radcliffe Department of Medicine, Oxford, UK).
Leukaemia-affiliated transcription factors, under the control of embryonic signals, drive HSC development
Vendredi 16 octobre 2015, 18:15 - 19:00 : AG
Vendredi 16 octobre 2015, 20:00 : Dîner
Vendredi 16 octobre 2015, 21:00 : Soirée de gala
Samedi 17 octobre 2015. Session 6
Moderateurs : Michele Goodhardt – Patrice Dubreuil
8:30 - 9:15 : Brian J Huntly (CIMR, Cambridge University, Cambridge)
Epigenetic dysfunction in haematological malignancies
9:15 - 9:30 : Coralie Hoareau-Aveilla (INSERM UMR1037 CRCT, Toulouse)
Reversal of microRNA-150 silencing disadvantages crizotinib-resistant NPM-ALK-positive cell growth
9:30 - 9:45 : Enguerran Mouly (INSERM U1170, IGR, Villejuif)
Tet2 deficiency in mice a new model of CLL-like disease development
9:45 - 10:15 : Pause
10:15 - 10:30 : Isabelle Plo (INSERM U1170, IGR, Villejuif)
Germline duplication of ATG2B and GSKIP predisposes to familial MPN and myeloid malignancies
10:30 - 11:15 : Bertrand Nadel (CIML, Marseille, France).
Site- and allele-specific polycomb dysregulation in T-cell leukaemia
11:15 - 11:30 : Remise des prix
Fin du congrès